Animal models : obesity, diabetes and IR

Animal models : obesity, diabetes and IR


In vivo lipids dynamics studies is mainly realized using rodent models. Parameters evaluation of is sometimes difficult due to the size of such models. An obese insulin-resistant dog model (OBEIR)conform to response observed in Human has been developed. However this canine model two fundamental differences compared to Human :

  • cholesterol is mainly transported by HDLs;
  • absence of CETP , “shunt enzyme”, who played a major role in Human.


  • Get validation limits of the current OBEIR model;
  • wider evaluation of response conformity to pharmacological, pathological and environmental stimuli;
  • refine model;
  • derive model to match specific needs;
  • explore other possible big size model (cat, minipig, horse);


  • Chromatography FPLC, HPLC, GC;
  • Lipoprotein kinetics;
  • Physical activity : GPS tracking, effort intensity;
  • Biological parameters : chemical assessments, RIA, IP, enzymatic activity, body composition, energy expenditure;

Study axes

Main results

  • dog breeds susceptibility with high LDLs levels in pathological conditions;
  • OBEIR model : support workout mimicking regular physical activity;
  • OBEIR model : response to drug treatment aiming pharmacological induced hypothyroidism;
  • encouraging preliminary results with candidate species (horse, cat, minipig…).


  1. Development axis shows encouraging results despite in situ difficulties;
  2. Multiple adaptations made it tremendously convenient;
  3. Wide margin to reveal potential of methodologies considered for this project.
Physiologist Bioinformatician